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Does ADHD Medication Work? When someone is given a prescription for ADHD medication, they often think about whether the medication will work and how long it will last. Here are some straightforward answers. Stimulants modify brain chemicals that relay messages about activity and attention. These include norepinephrine and dopamine. They are the first-line option for adults with ADHD. 1. Stimulants Stimulants are the most frequently prescribed medications for managing ADHD. They alter the activity