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Bacterial cellulose (BC) is a biopolymer of great significance to the medical, pharmaceutical, and food industries. However, a high concentration of carbon sources (mainly glucose) and other culture media components is usually required to promote a significant yield of BC, which increases the bioprocess cost. Thus, optimization strategies (conventional or statistical) have become relevant for the cost-effective production of bacterial cellulose. Additionally, this biopolymer may present new properties through modifications with exogenous