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Distress from LUTS was similar among different age groups and in the presence of VA. It was related to RUI (CR 7.187, 95 %CI 3.532, 10.841; p less then 0.0001) and being an ex-smoker (CR 5.189, 95 %CI 1.425. 6.952; p less then 0.007), and was inversely related to FSFI score (CR -0.314, 95 %CI -0.478, -0.149; p less then 0.0002), CONCLUSIONS In women across the menopausal age span, RUI, but not LUTS, is related to VA. The presence of LUTS is related to dyspareunia, and distress from LUTS is inversely related to sexuality. These results obt