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9 vs. 1.9mg/dL, p 0.001) and higher bilirubin levels (median 2.9 vs. 1.9mg/dL, p 0.001). Algorithms combining clinical laboratory criteria (AST 85U/L but 450 U/L, AST-to-ALT ratio 2, total bilirubin 5mg/dL) and administrative coding criteria yielded the highest PPV (96.4%, 95% CI 87.7-99.6) and the highest LR+ (43.0, 95% CI 10.6-173.5). Several algorithms demonstrated 100% PPV for definite AH in the UPHS external cohort. We have identified algorithms for AH hospitalizations with excellent PPV and LR+. Th