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Stimulants Are the Most Effective ADHD Medication For Adults The most frequently prescribed medication prescribed by healthcare professionals to treat ADHD in adults is stimulants. They increase the levels of certain chemicals (neurotransmitters) in your brain to increase focus and decrease the amount of impulsivity. Antidepressants, such as Strattera (atomoxetine) and Wellbutrin/Zyban, and Bupropion (bupropion) are also able to help control ADHD. They boost the levels of norepinep