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No patients exhibited alveolar osteitis or secondary infection. Compared with baseline, all groups showed significant reduction in socket volume at all observation time-points ( 0.05). The 50 mg acemannan group had a significantly greater reduction in socket volume compared with the control at all postoperative time-points ( 0.05). The 20 mg group had a significantly greater reduction in socket volume compared with the control at 3-months postoperatively ( 0.05). We conclude that acemannan increases bone healing at 3-