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How Does Medication For ADHD Work? The stimulants are among the most frequently ADHD medication prescribed. They boost the levels of brain chemicals, such as dopamine and norepinephrine. They include methylphenidate (Ritalin, Concerta), amphetamine and dextroamphetamine (Adderall) and the lisdexafetamine (Vyvanse). Doctors typically prescribe them in long-release formulations that last between six and eight hours or more. This reduces the f