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Cardiac dysfunction is amongst the important problems of sepsis, termed sepsis-induced myocardial dysfunction (SIMD), that is characterized by systolic and diastolic disorder of both edges of the heart. Mechanisms that subscribe to SIMD include an excessive inflammatory response, changed circulatory, microvascular status, nitric oxide (NO) synthesis disability, endothelial dysfunction, conditions of calcium regulation, cardiac autophagy anomaly, autonomic nervous system dysregulation, m