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05). Multivariate analysis identified four independent prognostic factors pathological type ( = 0.007), vascular tumor emboli ( = 0.044), Ki-67 index ( = 0.044), and SAEs ( = 0.004). CRS + HIPEC for DMPM treatment resulted in prolonged survival with acceptable safety. Tumor pathology and SAEs are key factors for successful CRS + HIPEC. CRS + HIPEC for DMPM treatment resulted in prolonged survival with acceptable safety. Tumor pathology and SAEs are key factors for successful CRS + HIPEC.Brain morphology is the result of functional f