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05). More than 75% of the pixels of FS at years 2 and 5 were preceded by pixels of baseline MNV. Most pixels of FS were preceded by components of neovascularization. Although one-quarter of MA was accounted for by pre-existing evidence of atrophy on OCT alone, the development of MA in areas of thick drusen, areas with and without subretinal MNV lesion, and areas without detectable OCT precursors argues that the development of MA is multifactorial and may follow, in part, a non-neovascular pathway. Most pixels of FS were preceded by compo