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Non Stimulant ADHD Medication Stimulants increase dopamine and neurotransmitters norepinephrine and norepine which aid in motivation, alertness, concentration, and effort. They also help enhance focus and concentration. Non-stimulant ADHD medications are typically prescribed when stimulants fail to work and cause unacceptably adverse side effects, or a person is unable to use them due to medical reasons. Clonidine (Kapvay), and guanfacine, (Intuniv) are examples. Stimulants Stimulants, a type non-stimulant ADHD medication, work by changing the way that nerves in