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Survival analysis data suggest that patients with risk group genotype (AG + GG) presenting jaundice have shorter overall survival. Our study suggests that the minor allele G of PARP1 rs1136410 (A/G) is a predisposing factor for gallbladder carcinogenesis and is significantly associated with early onset of the disease. Interestingly, the minor allele G is significantly more frequent in the patients with jaundice, lymph node metastasis and gallbladder wall thickness. Our study suggests that the minor allele G of PARP1 rs1136410 (A/G) is a p