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T3; P 0.05), N classification (negative vs. positive; P 0.001), degree of differentiation (G1 vs. G3, P 0.05; G2 vs. G3, P 0.05) and clinical stage (I-IIA vs. IIB-III; P 0.05). When MMP-14 was knocked down in ESCC cells, this induced cell cycle arrest, impairing their proliferative and invasive activity. MMP-14 is a key regulator of the proliferation and invasion of ESCC cells, making it a viable therapeutic target for the treatment of this cancer. MMP-14 is a key regulator of the proliferation and invasion of ESC