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Experimental results had been in close arrangement with solubility parameter predictions for systems with ΔδT less then 4.0 MPa1/2. A variety of Hansen solubility parameters with experimental drug-lipid miscibility tests are effectively applied to anticipate lipids with the best solubilizing possibility different API prior to manufacture of solid lipid nanoparticles and nanostructured lipid providers. © 2020 The Author(s).Vascular endothelial disorder is caused by dyslipidemia, high blood pressure, and deficie