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The specific (antimicrobial and antifungal) activity of the drug was confirmed in vivo using the following scheme of drug use the drug was instilled once a day, within 10-14 days in the ear canal, 2-5 drops of the drug in animals with external otitis and otitis media. Conclusion The rational combination of active components developed in this study is effective and safe for use in animals with microbial diseases of the ears. Copyright © Journal of Advanced Veterinary and Animal Research.Several animals have been in the limelight of basi