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The challenge remains open to submissions and all images are available for download.There is clinical evidence that suppressing the bone structures in Chest X-rays (CXRs) improves diagnostic value, either for radiologists or computer-aided diagnosis. However, bone-free CXRs are not always accessible. We hereby propose a coarse-to-fine CXR bone suppression approach by using structural priors derived from unpaired computed tomography (CT) images. In the low-resolution stage, we use the digitally reconstructed radiograph (DRR) image that i