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Major bleeding (no frailty, 9.6%; moderate frailty, 16.9%; moderate-to-severe frailty, 31.8%; P less then 0.001) and in-hospital mortality (no frailty, 8.4%; mild frailty, 15.4%; moderate-to-severe frailty, 27.3%; P less then 0.001) increased as frailty worsened. After adjusting for confounders, frailty ended up being independently related to higher mid-term all-cause mortality (risk proportion, 1.81; 95% self-confidence interval, 1.23-2.65; P=0.002). CONCLUSIONS Frailty in AMI patients age