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How Does ADHD Medication Work? Stimulants are the initial line of treatment for ADHD. They aid in regulating the levels of two brain chemical substances (neurotransmitters) that convey messages between neurons to improve attention and reduce hyperactivity. 20% of people are not responsive to stimulants like amphetamine or methylphenidate. This may be due to their body chemistry or other drugs they are taking. What are the symptoms of ADHD? If you suspect that your child has ADHD begin by visitin