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This research aims to explore whether sex, race, age, education, and marital status can significantly predict suicide ideation (SI) and suicidal attempts (SA) among adults with and without MDE; and to examine whether the association between MDE, SI, and SA changes after adjusting for age, education, and marital status as confounding factors while keeping race-sex as a constant variable. To reach this goal, data from the 2018 National Survey on Drug Use and Health were extracted and analyzed, producing 42,551 records. Study results show that among