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Purpose Olanzapine (OLZ) is an atypical antipsychotic agent that is characterized by low brain porousness due to hepatic first-pass metabolism. The present work aimed to develop radiolabeled OLZ and evaluate its biodistribution following intravenous (I.V.) and intranasal (I.N.) administration as a potential agent for brain diagnosis. The effect of colloidal tin oxides on the biodistribution of technetium-99m radiolabeled OLZ has been overcome by using sodium dithionite as a reducing agent instead of the commonly used stannous salts for