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05) were prevented by irisin. Despite it was not effective in preventing Trap and Cathepsin K mRNA increase, irisin induced a 2.8-fold increase of Osteoprotegerin (P less then .05) that might act for reducing osteoclastogenesis in microgravity. Our results provide evidence that irisin supports OB differentiation and activity in microgravity and it might represent a countermeasure to prevent bone loss in astronauts.M yrtucomvalones D-F ( 1 - 3 ), three new triketone-phloroglucinol-triketone adduct s, and three known ones ( 4 - 6 ) were obtained from Myrtus c