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Medication errors and unsafe medication practices are a leading cause of injury and avoidable harm worldwide. The aim of this review was to (i) explore and identify evidence-based strategies to teach medication calculation skills by determining the most common errors and assess the quality, level, and role of the evidence, and (ii) describe instruction strategies for drug calculation skills development or improvement based on seven research-based principles for smart teaching. Systematic review. CINAHL, PubMed, and PsycINFO. The review