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Multiple collagen genetics had been more highly expressed in the BPA-exposed fibroblasts resulting in increased collagen deposition into the adult mammary gland. This transcriptional reprogramming of BPA-exposed fibroblasts generates a less permeable extracellular matrix and a stiffer mammary gland. These phenotypes had been just observed in adult 12-week-old, not 4-week-old, mice. Also, diethylstilbestrol, recognized to increase breast cancer danger in humans, additionally incr