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Formation of the biocorona may have contributed to the reduced oxidative stress as well as toxicological impacts observed in cellular studies. The present work is the first to confirm persistent adsorption of biomolecules could occur on ingested nanomaterials in food digestae. More future studies are needed to study the in vivo impacts of the biocorona, and shed lights on how the biocorona affects the biotransformations and fate of the ingested nanomaterials, which may impose impacts on human health.As the global population ages, there is increased interest