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In addition, compared with control group, CIA group showed higher proportion of CD4+IL-22+ cells and higher level of IL-22 which then interestingly decreased after H2 therapy. Besides, the p-STAT3 and p-NF-κB were elevated in CIA mice compared with control group, and H2 treatment significantly inhibited them. Conclusion H2 can reduce the levels of CD4+IL-22+ cells and IL-22, and alleviate arthritis symptoms in CIA mice by inhibiting STAT3/NF-κB pathway.Objective To investigate the dynamic changes of IL-10 secretion B cells (B10 cells)
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