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IMPORTANCE Since current strategies for the treatment of multidrug-resistant tuberculosis (MDR-T and extensively drug-resistant tuberculosis (XDR-T have low efficacy and highly negative side effects, research on new treatments including novel drugs is essential for curing drug-resistant tuberculosis. Host-directed therapy (HDT) has become a promising idea to modulate host cell responses to enhance protective immunity against pathogens. Bazedoxifene (BZA), which belongs to a new generation of SERMs, shows the ability to inhibit the gr