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Because the dysfunction is current before signs take place, very early detection can be done, that might help out with avoidance and effective management of diabetic neuropathy. Plasma lactate is a marker of non-oxidative glucose metabolism associated with development to diabetic issues. We examined the effect of carbohydrate quality (glycemic index (GI)) and quantity (%kcal) on plasma lactate. We hypothesized that low GI (≤45 (g)) versus high (≥65 (G)) and low %kcal from carb (40% kcal (c)