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ts. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.AIM AND OBJECTIVE In this work 1,3-oxazoles were generated using multicomponent reaction of α-bromo ketones, alkyl (aryl) isothiocyanates, sodium hydride and catalytic amount of Fe3O4 MNPs in aqueous media at ambient temperature in good yields. Also, Fe3O4-MNPs were generated using Orange peel water extract as green procedure that reduce the ferric chloride solution. The nanoparticles that is generated via biosynthesis method have potentiall