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To test the association of alcohol consumption with total and cause-specific mortality risk. Prospective observational multi-centre population-based study. Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project. A total of 142 960 individuals (mean age 50±13 years, 53.9% men). Average alcohol intake by food frequency questionnaire, total and cause-specific mortality. In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95