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The non-polar extracts of E. clavarioides exhibited the highest cell growth inhibition activity with hexane extract reaching IC50 at 1 μg mL-1. The DCM extract of E. caerulescens reached IC50 at a concentration of 10 μg mL-1, while other extracts didn't show any activity. The hexane and DCM extracts of E. polygona exhibited the highest cell growth inhibition activity, reaching IC50 at a concentration of 10 μg mL-1. All 4 extracts of E. trigona didn't show cell growth inhibition. All Euphorbia species showed the presence of secondary me