https://www.selleckchem.com/pr....oducts/gsk2879552-2h
Immobilized metal-ion affinity chromatography (IMAC) used to purify recombinant proteins features a resin-bound 11 Ni(II)-iminodiacetic acid (IDA) complex. This hemi-saturated Ni(II)-IDA system containing exchangeable sites at the metal ion is re-cast as a surrogate of a coordinatively-unsaturated metalloenzyme active site, with utility for selecting compounds with metal-binding groups from mixtures as potential metalloenzyme inhibitors. Exchanging Ni(II) for other metal ions could broaden the scope of metalloenzyme target. This
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