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Finding the Best ADHD Medication For Adults Stimulants, such as methylphenidate (Ritalin) or amphetamine (Vyvanse), work quickly to boost and balance levels of brain chemicals. These medications can cause weight fluctuations, tics, and sleep issues in certain people. Atomoxetine and some antidepressants (like bupropion) are non-stimulant drugs that work slowly to help with ADHD symptoms. They increase a chemical in the brain that is known as norepinephrine. This helps enhance concentration and control of impulses. Stimulants ADHD medication is often