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Meanwhile, the PCA-derived MA component is employed to identify and exclude the MA-contaminated segments. To evaluate the new algorithm, we performed a comparative experiment (N = 22) with a cuffless MWPPG measurement device and used double-tube auscultatory BP measurement as a reference. The results demonstrate clearly the accuracy improvement enabled by the PCA-based operations on MWPPG signals, yielding errors of 1.44 ± 6.89 mmHg for systolic blood pressure and -1.00 ± 6.71 mm Hg for diastolic blood pressure. In conclusion, the propo