https://www.selleckchem.com/pr....oducts/gsk2982772.ht
5 years (3.5-11.3) and 21.5 kg (13.5-20.. The mean (standard deviation) of first-dose PK parameters of the LD group vs the NLD group were Cmax 6.1 (2.4) vs 4.1 (1.3) mg/L, AUC0-t 26.5 (12.5) vs 13.5 (3.6) mg/L*h, Vd 0.7 (0.4) vs 0.6 (0.3) L/kg, and t1/2 2.9 (0.6) vs 2.6 (0.4) h. There was no patient developed AKI by serum creatinine criteria. CONCLUSIONS CMS loading dose is beneficial for the improvement of colistin exposure without increased AKI. A higher daily dose of CMS should be considered especially for MDR-GNB treatment. V.D
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