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dings highlight the importance of independent evaluation of proprietary models before widespread operational use among COVID-19 patients. We found the EDI identifies small subsets of high- and low-risk COVID-19 patients with good discrimination although its clinical utility as an early warning system is limited by low sensitivity. These findings highlight the importance of independent evaluation of proprietary models before widespread operational use among COVID-19 patients.In this paper, a deterministic model characterizing the within-