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e post neoadjuvant therapy. This may inform guideline development, and enhance shared decision-making, at a time when therapeutic options for recurrence are expanding. To systematically review the problem of appetite loss after major abdominal surgery. Appetite loss is a common problem after major abdominal surgery. Understanding of etiology and treatment options is limited. We searched Medline, Cochrane Central Register of Controlled Trials, and Web of Science for studies describing postoperative appetite loss. Data were extracted to cl