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011), suggesting differential patterns of brain aging. This study demonstrates the feasibility of using MRE to assess HCsf microstructural integrity and suggests incorporation of these metrics to evaluate HC health in neurocognitive disorders.The interactions between proteins and nucleic acid sequences play many important roles in gene expression and some cellular activities. Accurate prediction of the nucleic acid binding residues in proteins will facilitate the research of the protein functions, gene expression, drug design, etc. In