https://www.selleckchem.com/pr....oducts/Sunitinib-Mal
In these mice, only the ubiquitous antigen-specific TR1 cells suppressed liver autoimmunity. Thus, the scope of antigen spreading in autoimmune disorders is larger than previously anticipated, involving specificities expected to be silenced by mechanisms of tolerance; the regulatory activity, but not the retention of autoreactive TR1 cells, requires local autoantigen expression.Tregs require specific epigenetic signatures to induce and maintain their suppressive function in the context of inflammation and cancer survei
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