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This article is protected by copyright. All rights reserved.PURPOSE Preclinical radiotherapy applications require dedicated irradiation methods that are high priced and not widely available. In this work, a clinical double origin 137 Cs mobile irradiator was adjusted to provide 1 cm diameter preclinical treatment beams utilizing a lead and stainless-steel custom-made collimator to take care of one or two mice at the same time. METHODS The dosimetric characteristics of the many various components of the sys