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Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) has been recognized as an effective tool for Breast Cancer (BC) diagnosis. Automatic BC analysis from DCE-MRI depends on features extracted particularly from lesions, hence, lesions need to be accurately segmented as a prior step. Due to the time and experience required to manually segment lesions in 4D DCE-MRI, automating this task is expected to reduce the workload, reduce observer variability and improve diagnostic accuracy. In this paper we propose an automated method fo