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Pathological changes of the pancreas and all the other indexes were observed at 3 and 24 h after operation. The serum IL-10 level, IkBα and LAMP2 levels in Sal M+S, Sal H+S and PDTC+S groups were higher than those in SAP 24 h group, while all the other indexes in these three groups were all lower significantly than those in SAP 24 h group. There was no significant difference in all indexes between Sal H+S and PDTC+S groups. High-dose Sal has an effectively therapeutic effect on SAP in rats, which was similar to PDTC. High-dose Sal has
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