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Compared with the control group, the serum LPS level showed significantly increased in DIO mice; however, no difference was found between the two groups in the serum Cre and BUN as well as in renal morphological structure. What's more, except that TLR2 mRNA level was not significantly different between the two groups, the mRNA levels of TLR4, MyD88, NF-κBp65 and TNF-α in the renal tissues of the DIO mice were significantly higher than those in the control group, and the protein levels of TLR4, MyD88 and NF-κBp65 in the renal tissues of the
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