https://www.selleckchem.com/pr....oducts/lomerizine-hc
Premature ovarian insufficiency (POI) is a highly heterogeneous disease, and up to 25% of cases can be explained by genetic causes. The transcription factor WT1has long been reported to play a crucial role in ovary function. Wt1-mutated female mice exhibited POI-like phenotypes. In this study, whole exome sequencing (WES) was applied to find the cause of POI in Han Chinese women. A nonsense variant in the WT1gene NM_024426.6c.1387CT(p.R463*) was identified in a non-syndromic POI woman. The variant is a heterozygous de novo mu
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