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Finally, the importance of elaborately modulating the carrier mobility and effective mass is emphasized, and a discussion of possible future strategies is presented to aim at further enhancing the thermoelectric performance.Methods for chemical modification of native proteins in a controlled fashion are in high demand. Here, a novel protocol that exploits bifunctional reagents for transient targeting of solvent exposed disulphides to direct the introduction of a single exogenous reactive thiol handle at a lysine side chain has been developed. The protocol h