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These effects were more pronounced in male mice than that in females. The promoting-effects of Cd on fibrosis and angiogenesis were further validated in hepatic stellate cells and liver sinusoidal endothelial cells. PPAR and ERBB signaling pathways were identified as the potential pathways to promote the toxicity of chronic Cd exposure. These findings provide a better understanding about the long-term influence of environmental Cd spanning the entire precancerous lesions-to-cancer formation cycle.Wastewater treatment plants are particular