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CONCLUSIONS The findings suggest that strengthening exercises, with or without associated manual therapy techniques and other resources, were the interventions with greatest power of treatment over the medium and long terms, for individuals with shoulder pain. These had greater therapeutic power than surgical procedures, electrotherapy or photobiomodulation.Protocol registration number in the PROSPERO database ID - CRD42018096578.BACKGROUND Age-related macular degeneration (AMD) is the third largest cause of blindness worldwide, accounting for 8.7% of all c