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To understand the efforts of B. longum subsp. longum (BL21) in the prevention of obesity, we investigated modifications when you look at the liver metabonomic phenotype and gut microbiota by ultraperformance liquid chromatography coupled with quadrupole time-of-flight size spectrometry and 16S ribosomal RNA gene sequencing in C57BL/6J male mice orally administered with BL21 for 8 days [high-fat diet (HFD)]. BL21 at 1 × 109 CFU·day-1 per mouse paid down the extra weight of mice