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In the last decade, epidemiological studies have linked even mild episodes of AKI to chronic renal disease (CKD) development, and inborn resistance appears to play a crucial role. The ischemic insult triggers an acute inflammatory reaction that is elicited by Pattern Recognition Receptors (PRRs), expressed on both infiltrating immune cells in addition to tubular epithelial cells (TECs). On the list of PRRs, Toll-like receptors (TLRs), their particular synergistic receptors, Nod-like receptors
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