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Experimental results suggest that the proposed method is able to obtain sO[Formula see text] estimates from multispectral photoacoustic measurements in silico, in vitro, and in vivo.The aim of this study was to compare the long-term implant survival and outcomes in patients with high-flexion cruciate-retaining (CR) or high-flexion posterior cruciate-substituting (PS) knee implants. A total of 253 knees (CR group 159 vs. PS group 94) were available for examination over a mean follow-up of 10 years. Clinical outcomes were assessed includi