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The mean partial pressure of oxygen (PaO ) was 102 with a mean fraction of inspired O (FiO ) of 44%. One patient was hyperoxic with a reduced OEI (17%). Five patients were normoxic, but 2 had a reduced OEF (mean 15.9%). Two patients were hypoxic but had increased systemic O utilization based on OEF or OEI. In select patients with severe COVID-19 respiratory failure, O delivery (DO ) was found to exceed O utilization. SpO targets based on systemic O utilization may help in reducing oxygen toxicity, especially in the absence of anaerobic m
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